In Family Guy,they seem to have different agreements on how Charlotte Rae (Mrs. Edna Garrett on Diffrnt Strokes and Facts of Life) should look like.
"Family Guy Viewer Mail #1"
In "SuperGriffins," Peter becomes her breasts with 'sunspots.' Season 3.
"Brian Goes Back to College"
In Season 4 episode, Brian watches TV and sees a writhered old hag named Mrs. Garrett. Oh yeah, the joke was that Joe was intersex.
"Brian's Got a Brand New Bag"
Season 8 episode, Lois has Charolette Rae ready for a joke. She looks much favorable than she did in season 4. I now see that it was a four year gap so that explains why she looks different.